【摘要】 目的：研究自体虹膜色素上皮细胞(iris pigment epithelium，IPE)移植治疗视网膜色素上皮细胞变性的效果。方法：采用酶机械分离酶消化法获取高纯度、高活力的IPE细胞用于移植，采用外路法将IPE细胞悬液移植入视网膜下腔。结果：IPE移植术后患者眼底移植区色素沉着减少，未见渗出，出血,视网膜平,视力入院时的0.15，术后2wk提高至0.2。多焦ERG显示移植区P1波平均反应密度上升。结论：自体虹膜色素上皮细胞移植有望成为视网膜色素上皮细胞变性疾病治疗的一新方法。
【关键词】 视网膜色素上皮变性;治疗;虹膜色素上皮;移植
Iris pigment epithelium transplantation for treating retinitis pigmentasa
GuoXing Xu, MaoSong Xie, Jian Guo, WeiDong Zheng, Qing He, Hong Lin, Shan Gao
Foundation item: Science Research Foundation of Major Project of Fujian Province, China (No. 2002Y002)
Ophthalmology Research Institution of Fujian Province, the First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, Fujian Province, China
Correspondence to: GuoXing Xu. Ophthalmology Research Institution of Fujian Province, the First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, Fujian Province, China. zjfmuxgx@pub5.fz.fj.cn
AbstractAIM: To investigate the effect of the iris pigment epithelium (IPE) transplantation for treating retinitis pigmentasa (RP).METHODS: RPE with high purity and activity was obtained from enzymemechanical separationenzyme digestion method, and then was transplanted to the subretinal space by extraocular surgery.RESULTS: After operation, chromatosis at transplantation region of fundus decreased, without effusion or hemorrhage. Retina was flat, and the visual acuity was improved to 0.2 at two weeks after operation compared with 0.15 when was admitted to hospital. P1 wave reaction density was increased from multifocus ERG. CONCLUSION: IPE cells transplantation may be a new method in treating RP. | 
